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| Size | Price | Stock |
|---|---|---|
| 5mg | $56 | 3-6 Days |
| 10mg | $83 | 3-6 Days |
| 25mg | $112 | 3-6 Days |
| 50mg | $160 | 3-6 Days |
| 100mg | $280 | 3-6 Days |
| 250mg | $520 | 3-6 Days |
| 500mg | $850 | 3-6 Days |
: Cat #: V1963 CAS #: 2719-05-3 Purity ≥ 98%
Description: FH1 (also known as NSC 12407, BRD-K4477) can enhance the functions of cultured hepatocytes by promoting differentiation of iPS-derived hepatocytes. FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 282.34 |
|---|---|
| Molecular Formula | C17H18N2O2 |
| CAS No. | 2719-05-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 56 mg/mL (198.3 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Synonyms | FH-1; NSC-12407; BRD-K4477; FH1; NSC12407; BRDK4477; FH 1; NSC 12407; BRD K4477; |
| Protocol | In Vitro | In vitro activity: In vitro, FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes. Cell Assay: FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion . |
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| Related Biological Data |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5418 mL | 17.7091 mL | 35.4183 mL | 70.8366 mL |
| 5mM | 0.7084 mL | 3.5418 mL | 7.0837 mL | 14.1673 mL |
| 10mM | 0.3542 mL | 1.7709 mL | 3.5418 mL | 7.0837 mL |
| 20mM | 0.1771 mL | 0.8855 mL | 1.7709 mL | 3.5418 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.