Naloxegol (formerly NKTR-118; AZ-13337019; PEGylated naloxol; Movantik; Moventig) is a peripherally-active/selective μ-opioid antagonist approved in 2014 for the treatment of opioid-induced constipation. It was approved in 2014 by FDA to treat constipation caused by opiate pain medications in adults with chronic pain that is not caused by cancer. Structurally, naloxegol is a pegylated analog of […]

EPZ-020411 (EPZ020411) 2HCl, the dihydrochloride salt of EPZ-020411, is a novel, potent and selective inhibitor of PRMT6 (protein arginine methyltransferase) with the potential to be used for cancer treatment. It inhibits PRMT6 with an IC50 value of 10 nM.

This product is discontinued due to commercial reason. Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib. Nedisertib (M-3814, MSC-2490484A) is a poten, selective and orally bioavailable inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 of

Latanoprostene (PF3187207; Latanoprostene BUNOD; LBN; BOL-303259-X; NCX116; Vesneo; Vyzulta) is a novel and potent nitric oxide (NO)-donating FP receptor (Prostaglandin F2α receptor) agonist with prostaglandin activity. It loweres intraocular pressure (IOP) more effectively than latanoprost in monkeys, dogs and rabbits. Latanoprostene was approved for use as an ophthalmic drug in the United States in 2017 […]

Norflurazon (Evital; Zorial; Solicam; H-9789; H-52143; H9789; H 52143; H 9789; H52143; Monometflurazon; Telok)is a weed control agent.

Indiplon (NBI-34060; CL-285,489) is a nonbenzodiazepine class of hypnotic sedative which works by enhancing the action of the inhibitory neurotransmitter GABA, like most other nonbenzodiazepine sedatives. It primarily binds to the α1 subunits of the GABAA receptors in the brain. Indiplon was approved for the treatment of insomnia. Like other non-benzodiazepine hypnotics, its mechanism of […]

SCH 54292 is a novel, potent and highly specific inhibitor of GDP exchange, also a potent Ras-GEF interaction inhibitor with IC50 of 0.7 uM.

FzM1.8 (FzM-1.8) is a novel and potent allosteric agonist of the Frizzled receptor FZD4 derived from FzM1. It activates FZD4 with pEC50 of 6.4.

Eberconazole Nitrate (Ebernet) is a potent azole antifungal agent and imidazole analogue with activity against dermatophytoses, candidiasis, and pityriasis.

Durlobactam sodium (ETX-2514 sodium, ETX 2514) is a broad-spectrum β-lactamase inhibitor used for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. ETX2514 broadly inhibits Ambler class A, C, and D β-lactamases. ETX2514 combined with sulbactam (SUL) in vitro restores sulbactam activity against Acinetobacter baumannii ETX2514-sulbactam (ETX2514SUL) is under development for the treatment of A. […]