Naloxegol | CAS 854601-70-0

Naloxegol

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$400	To Be Confirmed
100mg	$600	To Be Confirmed
250mg	$1150	To Be Confirmed
500mg	$1850	To Be Confirmed

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Cat #: V29078 CAS #: 854601-70-0 Purity ≥ 99%

Description: Naloxegol (formerly NKTR-118; AZ-13337019; PEGylated naloxol; Movantik; Moventig) is a peripherally-active/selective μ-opioid antagonist approved in 2014 for the treatment of opioid-induced constipation. It was approved in 2014 by FDA to treat constipation caused by opiate pain medications in adults with chronic pain that is not caused by cancer. Structurally, naloxegol is a pegylated analog of α-naloxol.

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Molecular Weight (MW)	651.78
Molecular Formula	C₃₄H₅₃NO₁₁
CAS No.	854601-70-0
Synonyms	AZ13337019; NKTR118; NKTR-118; AZ-13337019; PEGylated naloxol; Movantik

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5343 mL	7.6713 mL	15.3426 mL	30.6852 mL
5mM	0.3069 mL	1.5343 mL	3.0685 mL	6.1370 mL
10mM	0.1534 mL	0.7671 mL	1.5343 mL	3.0685 mL
20mM	0.0767 mL	0.3836 mL	0.7671 mL	1.5343 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.