Carboxyamidotriazole orotate is the orotate salt form of carboxyamidotriazole (CAI; RFE-007; L-651582; NSC-609974), which is a novel and potent inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases with anti-tumor, antiangiogenic and anti-inflammatory activity. Also an inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways.

Sermorelin acetate [GRF (1-29) amide (human)] is a peptide compound composed of 29-amino acids, and is a growth hormone-releasing hormone (GHRH) analogue used as a diagnostic agent. It is the shortest fully functional fragment of GHRH and is used as a diagnostic agent to assess growth hormone (GH) secretion. It is also used as doping […]

PRE084 (PRE-084) HCl is a novel, potent, high affinity and selective sigma 1 agonist with Ki values of 2.2 and 13091 nM for σ1 and σ2 receptors respectively.

Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analogue of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease […]

R306465, formerly known as JNJ-16241199, is a novel and potent inhibitor of hydroxamate-based histone deacetylase (HDAC) with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.

GA3-AM (Gibberellic Acid Acetoxymethyl Ester), a Gibberellin analogue (GA3), is a cell permeable chemical dimerizer that can induce rapid dimerization of GAIs and GID1.

NSI-189 is a novel and potent bioactive compound

24-Norursodeoxycholic acid (24-nor-Ursodeoxycholic acid; Norucholic acid; nor-UDCA), an an analog of ursodeoxycholic acid, is a side chain-shortened C23 homolog of UDCA with anti-inflammatory, anti-cholestatic, and anti-fibrotic activities. It is advantageous over Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

INCB3284 (INCB-3284) is a novel, potent and orally bioavailable CCR2 antagonist with the potential to be used for acute liver failure. Acts by inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM.

Caffeine is a naturally occurring methylxanthine found in some beverages and also used as a pharmacological agent. Caffeine’s most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types […]