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Nafarelin acetate hydrate

This product is for research use only, not for human use. We do not sell to patients.

Nafarelin acetate hydrate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$603-6 Days
10mg$903-6 Days
25mg$1353-6 Days
50mg$2003-6 Days
100mg$3503-6 Days
250mg$5803-6 Days
500mg$8503-6 Days

Cat #: V26346 CAS #: 86220-42-0 Purity ≥ 99%

Description: Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analogue of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, and to control ovarian stimulation in IVF. It is normally delivered via a nasal spray. Nafarelin acetate is marketed by Searle (now part of Pfizer) under the brand name Synarel.

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Molecular Weight (MW)1400.563
Molecular FormulaC68H89N17O16
CAS No.86220-42-0
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.7140 mL3.5700 mL7.1400 mL14.2800 mL
5mM0.1428 mL0.7140 mL1.4280 mL2.8560 mL
10mM0.0714 mL0.3570 mL0.7140 mL1.4280 mL
20mM0.0357 mL0.1785 mL0.3570 mL0.7140 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.