Nutlin-3a, the active enantiomer of Nutlin-3, is a novel and potent p53/MDM2 (murine double minute) protein protein interaction inhibitor with an IC50 of 90 nM in cell-free assays.

MX69 is a novel, potent and selective MDM2/XIAP dual inhibitor that has the potential use for treatment of cancer.

NSC 207895 is a novel anticancer agent that is able to suppress MDM2 with an IC50 of 2.5 μM, which leads to enhanced p53 stabilization/activation and DNA damage.

Eprenetapopt (APR-246; PRIMA-1MET), a methylated derivative of PRIMA-1 and a mutant p53 reactivator, is a novel and potent small molecule compound that is able to restore wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.

Siremadlin (formerly also known as NVP-HDM201; NVP-HDM-201; HDM-201; HDM201) is a novel, potent, highly specific and orally bioavailable MDM-2/p53 inhibitor with potential antitumor activity.

Nutlin-3, a tetra-substituted imidazoline, is a novel potent and selective small-molecule antagonist/inhibitor of murine double minute 2 (MDM2) with potential antitumor activities.

NVP-CGM097 sulfate (CGM097; NVP-CGM-097; NVPCGM097), the sulfate salt of NVP-CGM097 or CGM-097, is a novel, orally bioavailable and selective inhibitor of MDM2 (human homolog of double minute 2)-p53 interaction with antitumor activity.

RG7388 (also known as Idasanutlin; RG-7388; RO5503781) is a novel, potent and highly selective antagonist of the p53-MDM2 protein-protein interaction with potential antitumor activity.

Nutlin-3b, a less active/inactive isomer of nutlin-3, is a novel antagonist or inhibitor of p53/MDM2 (murine double minute 2) protein protein interaction with IC50 value of 13.6 μM.

A-1155463 (A1155463) is a novel highly potent and selective BCL-XL inhibitor with antitumor activity.