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Nutlin-3

This product is for research use only, not for human use. We do not sell to patients.

Nutlin-3
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$899Check With Us
500mg$1230Check With Us
1g$1845Check With Us
email: [email protected]        [email protected]

Cat #: V0040 CAS #: 890090-75-2 Purity ≥ 98%

Description: Nutlin-3, a tetra-substituted imidazoline, is a novel potent and selective small-molecule antagonist/inhibitor of murine double minute 2 (MDM2) with potential antitumor activities.

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Molecular Weight (MW)581.5
Molecular FormulaC30H30Cl2N4O4
CAS No.890090-75-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 100 mg/mL (171.9 mM)r
Water:<1 mg/mL (slightly soluble or insoluble)r
Ethanol: 30 mg/mL (51.59 mM)
SMILES CodeO=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=N[C@H](C3=CC=C(C=C3)Cl)[C@@H]1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O
SynonymsNutlin-3
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7197 mL8.5985 mL17.1969 mL34.3938 mL
5mM0.3439 mL1.7197 mL3.4394 mL6.8788 mL
10mM0.1720 mL0.8598 mL1.7197 mL3.4394 mL
20mM0.0860 mL0.4299 mL0.8598 mL1.7197 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.