NSC 207895
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1240 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V0041 CAS #: 58131-57-0 Purity ≥ 98%
Description: NSC 207895 is a novel anticancer agent that is able to suppress MDM2 with an IC50 of 2.5 μM, which leads to enhanced p53 stabilization/activation and DNA damage.
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| Molecular Weight (MW) | 279.25 |
|---|---|
| Molecular Formula | C11H13N5O4 |
| CAS No. | 58131-57-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 0.4 mg/mL (1.43 mM)r |
| Water:<1 mg/mL (slightly soluble or insoluble)r | |
| Ethanol: <1 mg/mL | |
| SMILES Code | CN1CCN(C2=CC=C([N+]([O-])=O)C3=NO[N+]([O-])=C32)CC1 |
| Synonyms | NSC-207895, NSC207895, XI-006, XI 006, XI006, NSC 207895, NSC179940, NSC-179940, NSC 179940 |
| Protocol | In Vitro | NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5810 mL | 17.9051 mL | 35.8102 mL | 71.6204 mL |
| 5mM | 0.7162 mL | 3.5810 mL | 7.1620 mL | 14.3241 mL |
| 10mM | 0.3581 mL | 1.7905 mL | 3.5810 mL | 7.1620 mL |
| 20mM | 0.1791 mL | 0.8953 mL | 1.7905 mL | 3.5810 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.