A-1155463
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 250mg | $2200 | Check With Us |
| 500mg | $3600 | Check With Us |
| 1g | $5400 | Check With Us |
: Cat #: V2657 CAS #: 1235034-55-5 Purity ≥ 98%
Description: A-1155463 (A1155463) is a novel highly potent and selective BCL-XL inhibitor with antitumor activity.
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| Molecular Weight (MW) | 669.79 |
|---|---|
| Molecular Formula | C35H32FN5O4S2 |
| CAS No. | 1235034-55-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (149.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 100 mg/mL (149.3 mM) | |
| SMILES Code | O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C (NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O |
| Synonyms | A-1155463; A 1155463; A1155463. |
| Protocol | In Vitro | A-1155463 shows picomolar binding affinity to BCL-XL (Ki＜0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki= 80 nM) and related proteins BCL-W (Ki= 19 nM) and MCL-1 (Ki> 440 nM) [2]. A-1155463 demonstrates strong growth inhibition of over half of the colorectal cell lines as defined by EC50 values ≤0.5 μM in the presence of 10 % FBS. |
|---|---|---|
| In Vivo | A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4930 mL | 7.4650 mL | 14.9301 mL | 29.8601 mL |
| 5mM | 0.2986 mL | 1.4930 mL | 2.9860 mL | 5.9720 mL |
| 10mM | 0.1493 mL | 0.7465 mL | 1.4930 mL | 2.9860 mL |
| 20mM | 0.0747 mL | 0.3733 mL | 0.7465 mL | 1.4930 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.