S 38093 is a novel brain-penetrant antagonist (inverse agonist) of the H3 (histamine H3) receptor with Ki of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively.
Doxylamine succinate (Decapryn; Unisom; Evigoa D), the succinate salt of Doxylamine, is an antihistamine drug that can be used as monotherapy (short-term sedative) or in combination with other drugs to relieve night-time allergy and cold.
Betahistine dihydrochloride (formerly PT 9; PT9; trade names Veserc, Serc, Hiserk, Betaserc, Vergo), the dihydrochloride salt of Betahistine which was pproved in EU in 1970s for treating Ménière’s disease, is a potent antagonist of histamine H3 receptor used as an anti-vertigo drug.
LML134 is a novel, orally bioactive and highly selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg.
Bromodiphenhydramine (Bromazine; trade names: Ambodryl, Ambrodil and others) hydrochloride is the hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties.
Epinastine HCl (WAL801CL; Alesion; Elestat; Epinastine; Epinastin; WAL-801CL), the hydrochloride salt of epinastine, is a potent antagonist of histamine H1 receptors without sedative side effects.
Histamine 2HCl (Ergamine), the dihydrochloride salt of histamine, is an organic nitrogen compound and an endogenous metabolite involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
JNJ-39758979 is a novel, potent and selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM.
Mizolastine (Mizollen; SL 85.0324; Mistalin; SL-850324; SL 850324; Mistamine; Mizolastina) is a histamine H1-receptor antagonist with anti-allergic effects.
Cyproheptadine HCl (Periactin; Eiproheptadine; Periactinol; Dronactin; Peritol), the hydrochloride salt form of cyproheptadine, is a histamine receptor antagonist (antihistamine) and also an antimuscarinic agent that has been used for the treatment of postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing’s syndrome.