Betahistine 2HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
25g	$200	Check With Us
50g	$300	Check With Us
100g	$450	Check With Us

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Cat #: V1236 CAS #: 5579-84-0 Purity ≥ 98%

Description: Betahistine dihydrochloride (formerly PT 9; PT9; trade names Veserc, Serc, Hiserk, Betaserc, Vergo), the dihydrochloride salt of Betahistine which was pproved in EU in 1970s for treating Ménière's disease, is a potent antagonist of histamine H3 receptor used as an anti-vertigo drug.

References: Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	209.12
Molecular Formula	C8H12N2.2HCl
CAS No.	5579-84-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 38 mg/mL (181.7 mM)r
	Water: 38 mg/mL (181.7 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Chemical Name: Methyl[2-(2-pyridyl)ethyl]amine dihydrochloride SMILES Code: CNCCC1=NC=CC=C1.[H]Cl.[H]Cl
Synonyms	PT-9; Betahistine dihydrochloride; Betahistine HCl; PT 9; PT9; trade names Veserc, Serc, Hiserk, Betaserc, Vergo.

Protocol	In Vitro	Betahistine dihydrochloride (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectively.
Protocol	In Vivo	Betahistine dihydrochloride (intraperitoneal or oral administration; 0.1-30 mg/kg; single dose) with acute administration has increased tele-methylhistamine (t-MeHA) levels with an ED50 of 0.4 mg/kg, indicating the inverse agonism. Besides, after acute oral administration, it increases t-MeHA levels with an ED50 of 2 mg/kg in male Swissmice

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.7819 mL	23.9097 mL	47.8194 mL	95.6389 mL
5mM	0.9564 mL	4.7819 mL	9.5639 mL	19.1278 mL
10mM	0.4782 mL	2.3910 mL	4.7819 mL	9.5639 mL
20mM	0.2391 mL	1.1955 mL	2.3910 mL	4.7819 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.