Cyproheptadine HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
25g	$850	Check With Us
50g	$1250	Check With Us
100g	$1875	Check With Us

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Cat #: V1246 CAS #: 969-33-5 Purity ≥ 98%

Description: Cyproheptadine HCl (Periactin; Eiproheptadine; Periactinol; Dronactin; Peritol), the hydrochloride salt form of cyproheptadine, is a histamine receptor antagonist (antihistamine) and also an antimuscarinic agent that has been used for the treatment of postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome.

References: Olivia A Lin, et al. The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function. PLoS One. 2014; 9(1): e87026.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	323.86
Molecular Formula	C21H21N.HCl
CAS No.	969-33-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 65 mg/mL (200.7 mM)r
	Water: <1 mg/mLr
	Ethanol: 20 mg/mL (61.8 mM)
Synonyms	Periactin; Eiproheptadine; Periactinol; Cyproheptadine Hydrochloride Sesquihydrate; Dronactin; Ciproheptadina; Peritol

Protocol	In Vitro	Cyproheptadine hydrochloride (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro
	In Vivo	Cyproheptadine hydrochloride (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo
	Animal model	C57BL/6 mice (8-10 weeks old)
	Dosages	1 mg/kg
	Administration	Intraperitoneal injection, daily, for 5 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0878 mL	15.4388 mL	30.8775 mL	61.7551 mL
5mM	0.6176 mL	3.0878 mL	6.1755 mL	12.3510 mL
10mM	0.3088 mL	1.5439 mL	3.0878 mL	6.1755 mL
20mM	0.1544 mL	0.7719 mL	1.5439 mL	3.0878 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.