Pitolisant (formerly BF2.649; Tiprolisant; BF2649; Ciproxidine; Wakix) is a novel, potent and selective nonimidazole inverse agonist of the recombinant human histamine H3 receptor with Ki of 0.16 nM.

Fexofenadine HCl (formerly MDL-16455A; Allegra; Terfenidine carboxylate; Telfast) is a potent histamine H1 receptor antagonist (antihistamine agent) used in the treatment of allergy symptoms such as hay fever, nasal congestion, and urticaria.

Chloropyramine hydrochloride (Alergosan, Allergan hydrochloride, Nilfan, Sinopen, Suprastin), the hydrochloride salt of Chloropyramine, is a potent antihistamine drug acting as a histamine receptor H1 antagonist.

Loratadine (formerly SCH29851; SCH-29851; Claritin; Loratidine; Clarityn; Alavert) is a potent and 2nd-generation histamine H1 receptor antagonist which has been approved for the treatment of allergies such as allergic rhinitis and urticaria. It also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM. Loratadine lacks central nervous system depressing effects such as […]

Ranitidine HCl (ZANTAC; AH-19065; AH 19065; Tanidina; Toriol; Fendibina; Gastridina; Sostril; Zantic; Ranisen), the hydrochloride salt of Ranitidine, is a histamine H2-receptor antagonist with an IC50 of 3.3 ± 1.4 uM.

Emedastine is a novel, potent, high affinity, selective, second generation H1-receptor antagonist with pre-clinically well-documented anti-allergic effects.

Ciproxifan (formerly known as FUB-359) is a highly potent and selective histamine H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

Alcaftadine (R89674; R-89674; trade name Lastacaft) is a potent H1 histamine receptor antagonist used as a topical medication to prevent eye irritation caused by allergic conjunctivitis. .

JNJ-5207852 is a novel and potent histamine antagonist selective for the H3 subtype.

Triprolidine HCl, the hydrochloride salt of Triprolidine, is an OTC antihistamine drug with anticholinergic activity.