Emedastine

This product is for research use only, not for human use. We do not sell to patients.

Emedastine
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1750Check With Us
250mg$2750Check With Us
500mg$4125Check With Us

Cat #: V3731 CAS #: 87233-61-2 Purity ≥ 98%

Description: Emedastine is a novel, potent, high affinity, selective, second generation H1-receptor antagonist with pre-clinically well-documented anti-allergic effects.

References: Andoh T, et al. Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406(1):149-52.

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Product Promise

Promise
Molecular Weight (MW)302.41
Molecular FormulaC17H26N4O
CAS No.87233-61-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: N/Ar
Ethanol: N/A
SynonymsAL-3432A; DSSTox_CID_26911; KB 2413; KB-2413; KG 2413; KG-2413; Emadine; Emedastine Difumarate; Emedastine fumarate; Rapimine;
ProtocolIn VivoEmedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg
Animal modelMale ICR mice 5-6 weeks of age
Dosages0.03, 0.1, 0.3 mg/kg
AdministrationOrally; 30 min before pruritogen injection
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3068 mL16.5338 mL33.0677 mL66.1354 mL
5mM0.6614 mL3.3068 mL6.6135 mL13.2271 mL
10mM0.3307 mL1.6534 mL3.3068 mL6.6135 mL
20mM0.1653 mL0.8267 mL1.6534 mL3.3068 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.