AGI-5198 (also know as IDH-C35; IDHC35; AGI-5198; AGI 5198) is a novel, highly potent and selective inhibitor of IDH1 (isocitrate dehydrogenase 1) R132H/R132C mutants with potential anticancer activity.

3-Methylpyrazole (also known as 3-MP) is a weak inhibitor of alcohol dehydrogenase, which are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+ to NADH).

Leflunomide (formerly also known as HWA486; Leflunomidum, trade/brand name Arava) is a potent pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug), it is used as an immunosuppressant agent for treating inflammatory conditions such as RA-rheumatoid arthritis.

Trilostane (also known as WIN 24540; Desopan; DB-011080; Win-24540; Modrastane) is a potent inhibitor of 3β-hydroxysteroid dehydrogenase that was used in the treatment of Cushing’s syndrome, Conn’s syndrome, and postmenopausal breast cancer in humans.

Vorasidenib (formerly known as AG-881; AG881) is a selective and orally bioavailable inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) with potential anticancer activity.

Glycyrrhizic Acid (also known as Glizigen; Liquorice; Glycyrrhizin), a naturally occurring triterpenoid saponin analog found in the licorice root, is a widely used anti-inflammatory agent but also has anticancer activities.

Teriflunomide (formerly HMR-1726; HMR1726; A771726; A-771726; trade name Aubagio), the active metabolite of the immunomodulator drug-leflunomide, is an orally bioavailable immunomodulatory agent with potential suppressing effects against immune systems.

NCT-501 (NCT501; NCT 501), a theophylline-based compound, is a novel, highly potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with potential anticancer activity.

BAY-1436032 is a novel and potent pan-mutant isocitrate dehydrogenase 1 (IDH1) inhibitor both in vitro and in vivo.

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 of 2.5 µM.