Teriflunomide

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$540	Check With Us
10g	$830	Check With Us
20g	$1245	Check With Us

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Cat #: V0867 CAS #: 108605-62-5 Purity ≥ 98%

Description: Teriflunomide (formerly HMR-1726; HMR1726; A771726; A-771726; trade name Aubagio), the active metabolite of the immunomodulator drug-leflunomide, is an orally bioavailable immunomodulatory agent with potential suppressing effects against immune systems.

References: R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	270.21
Molecular Formula	C12H9F3N2O2
CAS No.	108605-62-5
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 32 mg/mL (118.4 mM)rr
	Water: <1 mg/mLrr
	Ethanol: <1 mg/mL
SMILES Code	C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Synonyms	A77 1726, HMR-1726; A77 1726; Aubagio; A771726; A-771726; HMR1726; HMR 1726; teriflunomide; trade name: Aubagio.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.7008 mL	18.5041 mL	37.0083 mL	74.0165 mL
5mM	0.7402 mL	3.7008 mL	7.4017 mL	14.8033 mL
10mM	0.3701 mL	1.8504 mL	3.7008 mL	7.4017 mL
20mM	0.1850 mL	0.9252 mL	1.8504 mL	3.7008 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.