Vorasidenib | CAS 1644545-52-7

Vorasidenib

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1190	Check With Us
250mg	$2050	Check With Us
500mg	$3075	Check With Us

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Cat #: V2766 CAS #: 1644545-52-7 Purity ≥ 98%

Description: Vorasidenib (formerly known as AG-881; AG881) is a selective and orally bioavailable inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) with potential anticancer activity.

References: Fujii T, et al. Targeting isocitrate dehydrogenase (IDH) in cancer. Discov Med. 2016 May;21(117):373-80.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	414.74
Molecular Formula	C14H13ClF6N6
CAS No.	1644545-52-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 82 mg/mL (197.71 mM)r
	Water: <1 mg/mLr
	Ethanol: 82 mg/mL (197.71 mM)
SMILES Code	C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F
Synonyms	AG-881, AG 881, AG881, Vorasidenib

Protocol	In Vitro	Vorasidenib has strong antiproliferative activity against human glioblastoma U-87 MG pLVX-IDH2 R140Q-neo, fibrosarcoma HT-1080 and neurosphere TS603 cells, all with IC50s of less than 50 nM.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4111 mL	12.0557 mL	24.1115 mL	48.2230 mL
5mM	0.4822 mL	2.4111 mL	4.8223 mL	9.6446 mL
10mM	0.2411 mL	1.2056 mL	2.4111 mL	4.8223 mL
20mM	0.1206 mL	0.6028 mL	1.2056 mL	2.4111 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.