MK-8245 (MK8245; MK 8245) is a novel and potent liver-targeted inhibitor of stearoyl-CoA desaturase (SCD) with anti-diabetic and anti-dyslipidemic activities. It inhibits stearoyl-CoA desaturase with an IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. It exhibits high anti-diabetic and anti-dyslipidemic efficacy in vivo and a significantly […]

DHODH-IN-11 is a novel analog of Leflunomide with weak dihydroorotate dehydrogenase (DHODH) inhibitory activity, and has a pKa of 5.03.

Enasidenib (formerly AG221; CC90007; AG-221; CC-90007; Idhifa) is an orally bioactive, first-in-class, and selective inhibitor of IDH2 (Isocitrate dehydrogenase 2) with potential anticancer activity.