DHODH-IN-11
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $850 | Check With Us |
| 200mg | $1275 | Check With Us |
| 500mg | $2150 | Check With Us |
: Cat #: V39998 CAS #: 1263303-95-2 Purity ≥ 99%
Description: DHODH-IN-11 is a novel analog of Leflunomide with weak dihydroorotate dehydrogenase (DHODH) inhibitory activity, and has a pKa of 5.03.
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| Molecular Weight (MW) | 265.27 |
|---|---|
| Molecular Formula | C15H11N3O2 |
| CAS No. | 1263303-95-2 |
| SMILES Code | N#C/C(C(NC1=CC=C(C2=CC=CC=C2)C=C1)=O)=N\O |
| Synonyms | YNN-03952; YNN03952; YNN 03952; DHODH-IN-11; |
| Protocol | In Vitro | Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7697 mL | 18.8487 mL | 37.6974 mL | 75.3949 mL |
| 5mM | 0.7539 mL | 3.7697 mL | 7.5395 mL | 15.0790 mL |
| 10mM | 0.3770 mL | 1.8849 mL | 3.7697 mL | 7.5395 mL |
| 20mM | 0.1885 mL | 0.9424 mL | 1.8849 mL | 3.7697 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.