PAβN dihydrochloride (MC-207110; Phe-Arg-β-naphthylamide) is a novel and potent efflux pump inhibitor, acting on the MDR (multidrug resistance) efflux pump/transporters of some Gram-negative bacteria.

Chlorphenesin (NSC-6401) is a synthetic preservative and cosmetic biocide that helps prevent the growth of microorganisms.

KKL-35 is a novel, and potent small molecule inhibitor of trans-translation tagging reaction with IC50 of 0.9 µM and with broad-spectrum antibiotic activity.

Afabicin (Debio-1450; AFN-1720) is a prodrug of Debio1452 (afabicin desphosphono), acting as an enoyl-acyl carrier protein reductase (FabI) inhibitor.

Gramicidin A is a naturally occuring peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α).

Ampicillin Trihydrate [D-(-)-α-Aminobenzylpenicillin] is a transpeptidase inhibitor used as a broad-spectrum beta-lactam antibiotic by preventing bacterial cell wall formation.

PBTZ169 (PBTZ-169; Macozinone, an 8-Nitro-benzothiazinones (BTZs) analog) is a novel inhibitor of decaprenyl-phosphoribose-epimerase (DprE1) that displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. DprE1 is an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. Structure-activity relationship (SAR) studies revealed the 8-nitro group of the BTZ scaffold to be crucial for the mechanism […]

Valinomycin (formerly known a NSC 122023) is a novel and potent cyclic depsipeptide antibiotic originally isolated from Streptomyces fulvissimus, it acts as a potassium selective ionophore.

Epetraborole hydrochloride (also known as GSK2251052 hydrochloride and AN3365 hydrochloride) is a novel, potent and selective leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase. Epetraborole was under investigation for the treatment of infections caused by multidrug-resistant Gram-negative pathogens. GSK2251052 is a novel boron-containing antibiotic […]

Ceftizoxime is the third generation cephalosporin effective against Gram-negative and Gram-positive bacteria.