Gramicidin A

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1950	Check With Us
250mg	$3250	Check With Us
500mg	$4875	Check With Us

: [email protected] [email protected]

Cat #: V3684 CAS #: 11029-61-1 Purity ≥ 99%

Description: Gramicidin A is a naturally occuring peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α).

References: Takada Y, et al. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020 Oct 1;11(1):4935.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1882.332
Molecular Formula	C99H140N20O17
CAS No.	11029-61-1
SMILES Code	[H]C(N[C@H](C(NCC(N[C@@H](C)C(N[C@@H](C(N[C@@H](C)C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H](C(N[C@@H](CC7=CNC8=C7C=CC=C8)C(NCCO)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)=O)CC(C)C)=O)=O)=O)C(C)C)=O
Synonyms	Gramicdin A;

Protocol	In Vitro	Gramicidin A displays potent broad-spectrum antibiotic activity against Gram-positive strains, even multidrug-resistant strains.
	In Vivo	Gramicidin A (0.11 mg/kg; intratumoral injection; twice weekly for 14 days) inhibits the growth of RCC tumor xenografts.
	Animal model	Female hairless Nu/J mice, 6- to 8-week old, injected subcutaneously with a suspension of SN12C cells (1.0 × 106) in a 50% growth factor–reduced Matrigel solution
	Dosages	0.11 mg/kg body weight
	Administration	Intratumoral injection, twice weekly for 14 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.5313 mL	2.6563 mL	5.3126 mL	10.6251 mL
5mM	0.1063 mL	0.5313 mL	1.0625 mL	2.1250 mL
10mM	0.0531 mL	0.2656 mL	0.5313 mL	1.0625 mL
20mM	0.0266 mL	0.1328 mL	0.2656 mL	0.5313 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.