Oritavancin diphosphate (LY-333328; LY 333328; LY333328; trade name Orbactiv), the diphosphate of Oritavancin, is a semisynthetic lipoglycopeptide analog of vancomycin approved in 2014 by FDA as an antibiotic for the treatment of serious Gram-positive bacterial infections.

Benzoic acid is a novel and potent fungistatic compound.

Gepotidacin (formerly GSK2140944) is a novel, potent, first-in-class, triazaacenaphthylene antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV via a unique mechanism and has demonstrated in vitro activity against Neisseria gonorrhoeae, including drug-resistant strains, and also targets pathogens associated with other conventional and biothreat infections. Broth microdilution was used to evaluate the MIC and minimum […]

Ribocil-C is a novel, potenty and highly selective chemical modulator of bacterial riboflavin riboswitches.

Tiamulin (SQ-14055; SQ14055; SQ14055) is a novel and potent pleuromutilin antibiotic that has been used in veterinary medicine in particularly for pigs and poultry.

Levofloxacin Hemihydrate [(-)-Ofloxacin], a synthetic fluoroquinolone, is a broad-spectrum and third-generation fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

AX20017 is a highly selective low-molecular-weight inhibitor of protein kinase G (PknG) with an IC50 of 0.39 μM. The pathogenicity of mycobacteria such as Mycobacterium tuberculosis is closely associated with their capacity to survive within host macrophages. A crucial virulence factor for intracellular mycobacterial survival is protein kinase G (PknG), a eukaryotic-like serine/threonine protein kinase […]

Bedaquiline (TMC-207; R-207910; TMC207; R207910; Sirturo) is a potent and orally bioavailable medication approved to treat active TB/tuberculosis.

Sulfamonomethoxine is a long acting antibiotic of the sulfonamide class, acting as an inhibitor of dihydropteroate synthetase, thus leading to the blockage of the synthesis of folic acid.

4-Hydroxycoumarin, a coumarin analog, is a versatile heterocyclic scaffold that has been frequently applied in the synthesis of various organic compounds.