Dianemycin (Nanchangmycin) is a potent antiviral agent with a broad spectrum antiviral active against Zika virus.

Q203 is an imidazopyridine amide (IAP) compound that block Mycobacterium tuberculosis growth by targeting the respiratory cytochrome bc1 complex. It has the potential for the treatment of tuberculosis. Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse […]

Fosfomycin Tromethamine (MK0955) is a potent, blood-brain barrier penetrant phosphoenolpyruvate analog produced by Streptomyces and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties. Fosfomycin binds to and inactivates the enzyme enolpyruvate transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of […]

Proflavine, an acridine-derived fluorescent dye, is a slow-acting disinfectant with bacteriostatic action against many Gram-positive bacteria but less effective against Gram-negative organisms.

URB602 is a selective inhibitor of the monoacylglycerol lipase (MGL) which inhibits rat brain MGL enzyme with IC50 of 28±4 μM via a noncompetitive mechanism. MGL is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Pretreatment with URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. […]

Tulathromycin A (Tulathromycin and CP-472295) is a potent macrolide antibiotic that has been used for the treatment of bovine respiratory disease (BRD) in cattle and swine respiratory disease in pigs.

Lefamulin acetate (formerly BC3781; Xenleta), the acetate salt form of lefamulin, is a semi-synthetic, orally bioactive pleuromutilin antibiotic that acts as an inhibitor for the synthesis of bacterial protein.

Cefalothin sodium (Cefalotin sodium) is a potent β-lactam cephalosporin antibiotic agent with a wide range antibacterial activity against gram-positive and gram-negative bacteria.

Retapamulin (also known as SB-275833) is a novel and potent topical antibiotic of the pleuromutilin class approved by the FDA for treatment of impetigo in children. It binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM. It has low potential for the development of antibacterial resistance and […]

Cilastatin (formerly MK791; MK-0791; Recarbrio) is a renal dehydropeptidase inhibitor and a leukotriene D4 dipeptidase inhibitor with nephroprotective effects.