Afabicin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3375 | To Be Confirmed |
| 200mg | $5060 | To Be Confirmed |
| 500mg | $8540 | To Be Confirmed |
: Cat #: V10423 CAS #: 1518800-35-5 Purity ≥ 99%
Description: Afabicin (Debio-1450; AFN-1720) is a prodrug of Debio1452 (afabicin desphosphono), acting as an enoyl-acyl carrier protein reductase (FabI) inhibitor.
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| Molecular Weight (MW) | 485.43 |
|---|---|
| Molecular Formula | C23H24N3O7P |
| CAS No. | 1518800-35-5 |
| SMILES Code | O=P(O)(OCN1C(CCC2=CC(/C=C/C(N(C)CC(O3)=C(C)C4=C3C=CC=C4)=O)=CN=C12)=O)O |
| Synonyms | AFN 1720; AFN1720; Afabicin; Debio 1450; Debio-1450; Debio1450; AFN-1720; |
| Protocol | In Vitro | Afabicin (Debio1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively. Debio1452 also inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0600 mL | 10.3001 mL | 20.6003 mL | 41.2006 mL |
| 5mM | 0.4120 mL | 2.0600 mL | 4.1201 mL | 8.2401 mL |
| 10mM | 0.2060 mL | 1.0300 mL | 2.0600 mL | 4.1201 mL |
| 20mM | 0.1030 mL | 0.5150 mL | 1.0300 mL | 2.0600 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.