Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as […]
Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
Alprenolol (alfeprol, alpheprol) is a potent and non-selective beta blocker as well as 5-HT1A receptor antagonist, used in the treatment of angina pectoris.
Asenapine HCl (Org-5222; HSDB 8061; Saphris; Sycrest) is a potent antagonist of multiple targets including serotonin, norepinephrine, dopamine and histamine receptors.
Quetiapine Fumarate (also known as ICI-204636; trade name Seroquel) is a dibenzothiazepine-based atypical antipsychotic agent acting as a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor.
CP-809101 HCl (CP809101), the hydrochloride salt of CP-809101, is a novel, potent and selective 5-HT2C receptor agonist with antipsychotic effects.
GSK163090 is novel, potent, selective, and orally bioavailable antagonist of the 5-HT1A/B/D receptor that has the potential to be used as a fast-onset antidepressant/anxiolytic.
SB269970 (SB-269970A) is a novel and potent 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
Tropisetron (also known as ICS 205-930) is a novel, potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist, used to treat nausea and vomiting following chemotherapy.
Latrepirdine HCl (Dimebon; Dimebolin; Dimeboline; Preparation 84), the hydrochloride salt of Latrepirdine, is an orally bioactive, neuroactive and non-selective antihistamine drug with the potential to be used for Alzheimer’s disease and Huntington’s disease.