Fluvoxamine maleate (DU23000 maleate)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$560	Check With Us
2g	$900	Check With Us
5g	$1355	Check With Us

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Cat #: V1017 CAS #: 61718-82-9 Purity ≥ 98%

Description: Fluvoxamine Maleate (formerly DU 23000; MK264; MK 264; DU-23000; Faverin, Fevarin, Floxyfral, Luvox), the maleate salt of Fluvoxamine which is an approved antidepressant drug, is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) used in the treatment of a variety of diseases including obsessive-compulsive disorder, major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).

References: Ginsburg, B.C., J.W. Pinkston, and R.J. Lamb, The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food. Behav Pharmacol, 2012. 23(2): p. 134-42.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	434.41
Molecular Formula	C14H18F3N2O2.C4H4O4
CAS No.	61718-82-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 87 mg/mL (200.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 87 mg/mL (200.3 mM)
Solubility In Vivo	Chemical Name: 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine maleate InChi Key: LFMYNZPAVPMEGP-PIDGMYBPSA-N InChi Code: InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1- SMILES Code: FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F.O=C(O)/C=CC(O)=O
Synonyms	DU-23000 maleate; Fluvoxamine maleate, DU 23000; MK264; MK 264; DU23000; Faverin, Fevarin, Floxyfral, Luvox; MK-264;

Protocol	In Vitro	Fluvoxamine maleate (DU-23000 maleate) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3020 mL	11.5099 mL	23.0197 mL	46.0395 mL
5mM	0.4604 mL	2.3020 mL	4.6039 mL	9.2079 mL
10mM	0.2302 mL	1.1510 mL	2.3020 mL	4.6039 mL
20mM	0.1151 mL	0.5755 mL	1.1510 mL	2.3020 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.