Prucalopride (Motegrity; R-108512; R 108512; Resolor; Resotran; R108512; Prudac), a novel enterokinetic compound and the first representative drug of the benzofuran class of laxatives, is a selective and high affinity 5-HT (serotonin) receptor agonist with Kis of 2.5 nM and 8 nM for 5-HT4A and 5-HT4B receptor, respectively.
Puerarin (Kakonein), a naturally occuring isoflavone isolated from the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
Vortioxetine (Lu-AA21004; Lu-AA-21004; Trintellix and Brintellix) is an approved anti-depressant drug acting as an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator.
Rizatriptan Benzoate (Maxalt; formerly MK 0462; MK 462) is a potent and selective agonist at serotonin 5-HT1B and 5-HT1D receptors with anti-migraine activity.
Palonosetron (formerly RS-25259, RS-25259 197; trade name: Aloxi and Akynzeo) is a 5-HT3 antagonist approved for use in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Clozapine (LX 100129; HF1854, LX100129; Leponex; Fazaclo; CLOZARIL; Clozapin; Clozaril) is an atypical antipsychotic drug wand a 5-HT antagonist used in the treatment of schizophrenia.
Frovatriptan Succinate (KB-295988; LS-173538; FT-0668872; D04264; Miguard; SB 209509), the succinate salt of frovatriptan, is a synthetic triptan that acts as an agonist of the serotonin (5-HT) receptor.
Clomipramine HCl (G-34586; G34586; Trade names: Anafranil, Clomicalm), the hydrochloride salt of clomipramine which is a tricyclic antidepressant (TCA), is a potent blocker of serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) with Ki of 0.14, 54 and 3 nM, respectively.
Duloxetine HCl (formerly LY-248686 HCl; LY248686; trade names Cymbalta; Yentreve), the hydrochloride salt of Duloxetine which is an approved antidepressant medication, is a potent serotonin-norepinephrine reuptake inhibitor (SNRI) with potential anti-depressive activity.
Palonosetron HCl (formerly RS-25259, RS-25259, RS 25259 197, RS-25259197; trade names: Aloxi and Akynzeo), an approved antiemetic drug, is a potent 5-HT3 antagonist that has been used in the prevention and treatment of chemotherapy-induced nausea and vomiting.