Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.

SPD-304 is a novel, potent and selective inhibitor of tumor necrosis factor α (TNFα) with an IC50 of 22 µM for preventing binding to the TNF Receptor 1 (TNFR1).

(S)-Tipifarnib is an inactive enantiomer of Tipifarnib to be used as a negative control.

Necrostatin-1 (Nec-1) is a novel, potent and specific RIP1 (receptor-interacting protein 1) kinase inhibitor that inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.

Hypaconitine is a novel and potent voltage-gated Na channel modulator.

(Rac)-Benpyrine, the racemic mixture of Benpyrine, is a potent and orally bioactive TNF-α inhibitor with the potential for TNF-α mediated inflammatory and autoimmune disease research.

Semapimod 4HCl, the tetrahydrochloride salt of Semapimod mesylate (AXD 455; AIDS-121302; CNI-1493), is a novel and potent cytokine inhibitor that inhibits the production of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Mesaconitine is a novel and potent bioactive compound.

AX-024 is a novel, potent and orally bioavailable inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 1 nM).

LY303511 is an analog of LY294002 and is also known as NV-128 and EM 101.