Hispidol
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1250 | To Be Confirmed |
| 1g | $1850 | To Be Confirmed |
| 5g | $4680 | To Be Confirmed |
: Cat #: V30065 CAS #: 5786-54-9 Purity ≥ 99%
Description: Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.
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| Molecular Weight (MW) | 254.24 |
|---|---|
| Molecular Formula | C15H10O4 |
| CAS No. | 5786-54-9 |
| SMILES Code | O=C1C2=CC=C(O)C=C2O/C1=C\C3=CC=C(O)C=C3 |
| Synonyms | Hispidol; (Z)-Hispidol |
| Protocol | In Vitro | Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression. |
|---|---|---|
| In Vivo | The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9333 mL | 19.6665 mL | 39.3329 mL | 78.6658 mL |
| 5mM | 0.7867 mL | 3.9333 mL | 7.8666 mL | 15.7332 mL |
| 10mM | 0.3933 mL | 1.9666 mL | 3.9333 mL | 7.8666 mL |
| 20mM | 0.1967 mL | 0.9833 mL | 1.9666 mL | 3.9333 mL |
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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