UTL-5g is a novel and potent chemoprotective agent, TNF-α inhibitor.

UCB-9260 (UCB9260; UCB 9260) is an oral anti-inflammatory agent with the potential to treat autoimmune diseases such as rheumatoid arthritis and Crohn’s disease.

REN-1189 is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.

Pomalidomide (formerly also known as CC-4047 or actimid), an analog of thalidomide, is a potent and orally bioavailable immunomodulatory molecule with antineoplastic activity.

Bioymifi is an DR5 activator (Kd = 1.2 µM; IC50 = 2 µM).

QNZ (also known as EVP-4593 or CAY-10470), a quinazoline derivative, is a novel and potent NF-κB inhibitor, which shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in human Jurkat T cells, respectively.

Thalidomide (trade names Immunoprin, Contergan and Thalomid among others) is a potent immunomodulatory agent and a drug approved in the 1950s.

Homoplantaginin is a naturally occurring flavonoid isolated from Salvia plebeia (a traditional Chinese medicine), exhibits anti-inflammatory and antioxidant activity by inhibiting TNF-α, IL-6 mRNA expression, and IKKβ and NF-κB phosphorylation.

KR-33494 is a fluorescent-tagged and biotin-tagged probe of a potent inhibitor for Fas-mediated cell death (FAF1).

R-7050 (R7050) is a novel, potent and selective tumor necrosis factor/ TNF-α receptor antagonist acting by blocking receptor-adaptor molecule complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding.