Semapimod tetrahydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1500 | To Be Confirmed |
| 200mg | $2250 | To Be Confirmed |
| 500mg | $3795 | To Be Confirmed |
: Cat #: V14615 CAS #: 164301-51-3 Purity ≥ 99%
Description: Semapimod 4HCl, the tetrahydrochloride salt of Semapimod mesylate (AXD 455; AIDS-121302; CNI-1493), is a novel and potent cytokine inhibitor that inhibits the production of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
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| Molecular Weight (MW) | 890.74 |
|---|---|
| Molecular Formula | C34H56Cl4N18O2 |
| CAS No. | 164301-51-3 |
| SMILES Code | O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl |
| Synonyms | AIDS121302; AIDS-121302; Semapimod HCl; CNI1493; CNI-1493; CNI1493; AXD-455; AXD 455; AXD455 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.1227 mL | 5.6133 mL | 11.2266 mL | 22.4532 mL |
| 5mM | 0.2245 mL | 1.1227 mL | 2.2453 mL | 4.4906 mL |
| 10mM | 0.1123 mL | 0.5613 mL | 1.1227 mL | 2.2453 mL |
| 20mM | 0.0561 mL | 0.2807 mL | 0.5613 mL | 1.1227 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.