SRT3025 is an orally bioactive small molecule activator of the SIRT1 enzyme.

AK-1 (AK1) is a novel and potent SIRT2 Inhibitor II (IC50 of 12.5 μM) with anti-Alzheimer’s disease and anticancer activity.

CAY10602 (CAY-10602) is a novel and potent SIRT1 activator.

SRT1720 (formerly known as CAY10559) is a novel and selective SIRT1 activator with an EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.

SIRT7 inhibitor 97491 is a novel SIRT7 inhibitor with antitumor activity.

AK-7 (also known as AK7, CS-3223 and GL-8955) is a novel, selective, cell- and brain-permeable SITR2 inhibitor with the potential to be used for the treatment of Parkinson’s disease and Huntington’s disease (HD).

Lithospermic acid B (Dan Shen Suan B, Salvianolic acid B) is a naturally occuring and potent antioxidant which is water-soluble and found in Salvia extract.

SRT1720 HCl (formerly known as CAY10559 HCl), the hydrochloride salt of SRT1720, is a novel, potent and selective SIRT1 (Sirtuin 1) activator with potential anticancer activity and is a promising new therapeutic agent for treating type 2 diabetes.

Splitomicin (known also as Splitomycin), a lactone derived from naphthol, is a potent, cell-permeable and selective inhibitor of NAD(+)-dependent histone deacetylase (HDAC) Sir2p with potential antineoplastic activity.

Salermide is a potent inhibitor of Sirt1/2 (Sirtuin 1/2) with a strong cancer-specific proapoptotic effect mediated by Sirt1.