CAY-10602 HCl, the hydrochloride salt of CAY10602, is a novel and potent SIRT1 activator identified from HTS/high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.

Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.

Thiomyristoyl, a thiomyristoyl lysine compound, is a novel, potent and specific SIRT2 inhibitor with IC50 of 28 nM.

3-TYP [3TYP; full/chemical name: 3-(1H-1,2,3-triazol-4-yl) pyridine)] is a novel, potent and selective SIRT3 inhibitor (IC50 = 16 nM) with high selectivity for SIRT3 over SIRT1 (IC50=88 nM) and SIRT2 (IC50=92 nM).

PROTAC Sirt2 Degrader-1 is a novel, potent PROTAC (proteolysis targeting chimera) which was identified based on the combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly potent and isotype-selective Sirt2 inhibitors with thalidomide, a bona fide cereblon ligand.