Lithospermic acid B
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 250mg | $730 | Check With Us |
| 500mg | $1100 | Check With Us |
| 1g | $1650 | Check With Us |
: Cat #: V11213 CAS #: 121521-90-2 Purity ≥ 98%
Description: Lithospermic acid B (Dan Shen Suan B, Salvianolic acid B) is a naturally occuring and potent antioxidant which is water-soluble and found in Salvia extract.
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| Molecular Weight (MW) | 718.61 |
|---|---|
| Molecular Formula | C36H30O16 |
| CAS No. | 121521-90-2 |
| SMILES Code | O=C([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(OC(C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)OC(C(O)=O)CC5=CC=C(O)C(O)=C5 |
| Synonyms | Lithospermic acid B; Salvianolic acid B; Danfensuan B; |
| Protocol | In Vitro | Salvianolic acid B (SA-B) 1 and 10 micromol/L decrease the cell active TGF-beta1 secretion by 63.3 % and 15.6 % of the control, down-regulat pro-collgen alpha1(I) mRNA expression to 77.0% and 51.8% respectively (P<0.05). SA-B 1 and 10 micromol/L also inhibit MAPK activity by 1 to 2 fold respectively. |
|---|---|---|
| In Vivo | Salvianolic acid B (SalB) (5 mg · kg-1 · h-1) significantly attenuates LPS-induced pulmonary microcirculatory disturbance, including the increase in leukocyte adhesion and albumin leakage. In addition, LPS increases pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor [alpha] and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhances the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, whereas it decreases the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which are attenuated by SalB pretreatment[1]. SalB administration (10 mg/kg) significantly ameliorate the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that are observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduce inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which are increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescue the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3916 mL | 6.9579 mL | 13.9158 mL | 27.8315 mL |
| 5mM | 0.2783 mL | 1.3916 mL | 2.7832 mL | 5.5663 mL |
| 10mM | 0.1392 mL | 0.6958 mL | 1.3916 mL | 2.7832 mL |
| 20mM | 0.0696 mL | 0.3479 mL | 0.6958 mL | 1.3916 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.