Nicotinamide (Vitamin B3; Niacinamide; Nicotinic acid amide), a water-soluble and active form of vitamin B3, is a potent and active component of coenzymes NAD and NADP.

SRT2104 (formerly GSK-2245840; SRT2104; GSK2245840; SRT-2104) is a novel, first-in-class, brain penetrant, and highly selective small molecule activator of SIRT1 (Sirtuin 1) with potential use for neurodegenerative diseases.

Resveratrol, also known as trans-Resveratrol, SRT-501 and RM-1812, is a naturally occuring phytoalexin produced by several plants with anti-cancer, antioxidant, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Sirtinol is a cell-permeable and specific inhibitor of the sirtuin deacetylase 1/2 (SIRT1/2) with potential anticancer and anti-inflammatory activity.

OSS_128167 (formerly SIRT6-IN-1) is a novel, potent and selective SIRT6 inhibitor with IC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.

Fisetin (Fustel; CCRIS9034; NSC40701; 3, 7, 3′, 4′-tetrahydroxyflavone) is a naturally occuring and dietary flavonoid isolated from/found in a variety of fruits and vegetables (i.e. strawberries, apples, persimmons, onions and cucumbers).

Cambinol (formerly NSC-112546) is a potent SIRT (silent information regulator enzymes) inhibitor with IC50 values of 56 and 59 μM for SIRT1 and SIRT2, respectively.

Selisistat (formerly SEN-0014196; EX-527) is a novel, highly potent and selective inhibitor of SIRT1 (Sirtuin1, a NAD-dependent and class III histone deacetylase enzyme) with important biological activity.

SirReal2 is a novel, highly potent and isoform-selective inhibitor of Sirt2 (Sirtuin 2) with potential anticancer and anti-inflammatory activity.

AGK2 is a novel, potent, and selective inhibitor of SIRT2 (sirtuin 2, histone deacetylase) with potential anti-inflammatory activity.