MG-132 (R) (R-isomer of MG-132), a peptide aldehyde, is a novel, potent, non-specific, cell permeable and reversible inhibitor 20S proteasome inhibitor, with IC50 of 24.2 nM for the β5 chymotrypsin-like active site.

Bortezomib (formerly also known as PS-341; trade name Velcade among others), a dipeptide boronic acid derivative, is cell-permeable, reversible, potent and highly selective inhibitor of 20S proteasome with potential antitumor activity.

Marizomib (formerly also known as ML-858, NPI-0052 and Salinosporamide A), a naturally-occurring salinosporamide extracted from the marine actinomycete Salinospora tropica, is a potent and selective 20S proteasome inhibitor (IC50 = 1.3 nM) with potential antineoplastic activity.

PI-1840 (PI1840; PI 1840) is a reversible/non-covalent and selective inhibitor of chymotrypsin-like (CT-L) activity of proteasome with potential anticancer activity.

Celastrol (also called tripterine) is a naturally occurring pentacyclic nortriterpen quinone and a remedial ingredient found in the root extracts of Tripterygium Wilfordi (Thunder of God vine) and Celastrus Regelii.

26S proteasome inhibitor I is a novel and potent inhibitor of 26S proteasome with potential anticancer activity.

DD1 inhibitor(3,3′-Diamino-4′-methoxyflavone) is a novel and histone deacetylase inhibitor.

PD 150606 is novel, potent, selective, and cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively.

Alicapistat (also known as ABT957; ABT-957) is a novel, potent, selective and orally bioactive inhibitor of human calpains 1 and 2 whose overactivation has been linked to Alzheimer disease (AD).

RAMB4 (PTP1B-IN-9) is a novel and potent ubiquitin-proteasome system (UPS)-stressor.