CELASTROL | CAS 34157-83-0

CELASTROL

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$430	Check With Us
1g	$645	Check With Us
5g	$1630	Check With Us

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Cat #: V0693 CAS #: 34157-83-0 Purity ≥ 98%

Description: Celastrol (also called tripterine) is a naturally occurring pentacyclic nortriterpen quinone and a remedial ingredient found in the root extracts of Tripterygium Wilfordi (Thunder of God vine) and Celastrus Regelii.

References: Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	450.61
Molecular Formula	C29H38O4
CAS No.	34157-83-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 90 mg/mL (199.7 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	O=C([C@@](CC[C@]1(C)CC[C@]2(C)C3=CC=C4C(C)=C5O)(C)C[C@@]1([H])[C@]2(C)CC[C@@]3(C)C4=CC5=O)
Synonyms	Celastrol; Tripterin; Tripterine;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2192 mL	11.0961 mL	22.1921 mL	44.3843 mL
5mM	0.4438 mL	2.2192 mL	4.4384 mL	8.8769 mL
10mM	0.2219 mL	1.1096 mL	2.2192 mL	4.4384 mL
20mM	0.1110 mL	0.5548 mL	1.1096 mL	2.2192 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.