DD1 inhibitor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1250 | Check With Us |
| 250mg | $1950 | Check With Us |
| 500mg | $2925 | Check With Us |
: Cat #: V2294 CAS #: 187585-11-1 Purity ≥ 99%
Description: DD1 inhibitor(3,3'-Diamino-4'-methoxyflavone) is a novel and histone deacetylase inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 282.29 |
|---|---|
| Molecular Formula | C16H14N2O3 |
| CAS No. | 187585-11-1 |
| Synonyms | DD1 |
| Protocol | In Vitro | DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates. DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation. DD1 induces cell cycle arrest at G2/M phase and apoptosis. DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5425 mL | 17.7123 mL | 35.4246 mL | 70.8491 mL |
| 5mM | 0.7085 mL | 3.5425 mL | 7.0849 mL | 14.1698 mL |
| 10mM | 0.3542 mL | 1.7712 mL | 3.5425 mL | 7.0849 mL |
| 20mM | 0.1771 mL | 0.8856 mL | 1.7712 mL | 3.5425 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.