ML133 HCl, the hydrochloride salt of ML-133, is a novel, potent and selective inhibitor of the inward-rectifier potassium channel 2 (Kir2) identified from a high-throughput screening (HTS) of more than 300,000 small molecules.

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).

Ciclopirox ethanolamine (formerly HOE-296; HOE296; Ciclopirox olamine), the ethanolamine salt of Ciclopirox, is a novel, investigational, synthetic, potent and broad-spectrum antifungal agent working as an iron chelator and used as an antifungal agent for topical dermatologic treatment of superficial mycoses.

Repaglinide (AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm) is a potent and short-acting potassium channel blocker with antidiabetic activity.

Amifampridine phosphate (trade name: Firdapse; pyridine-3,4-diamine, 3,4-diaminopyridine, 3,4-DAP) is the phosphate salt of Amifampridine, which is an FDA approved drug used mainly in the treatment of a number of rare muscle diseases such as Lambert-Eaton myasthenic syndrome (LEMS) in adults (It gained US approval in November 2018).

NS3623 (NS-3623) is a novel and potent (hERG) and KV4.3 channel activator with antiarrhythmic effects.

F-1 is a novel and potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.

MK-7145 is a novel, potent, selective and orally bioactive ROMK inhibitor with IC50 of 0.045 μM and has the potential for the treatment of hypertension and heart failure.

Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.

GAL-021 is a novel and potent conductance calcium-activated potassium channel (BKCa-channel) blocker