MK-7145
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $3250 | To Be Confirmed |
| 100mg | $4875 | To Be Confirmed |
| 200mg | $7310 | To Be Confirmed |
: Cat #: V4305 CAS #: 1255204-84-2 Purity ≥ 98%
Description: MK-7145 is a novel, potent, selective and orally bioactive ROMK inhibitor with IC50 of 0.045 μM and has the potential for the treatment of hypertension and heart failure.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 466.53 |
|---|---|
| Molecular Formula | C26H30N2O6 |
| CAS No. | 1255204-84-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | MK-7145 (Compound 12) is screened against other members of the Kir family of channels. It doed not show any significant activity on Kir2.1, Kir2.3, Kir4.1, or Kir7.1 channels when tested at concentrations up to 30 μM. MK-7145 is also selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50>30 μM). In a broad counterscreen panel conducted at Panlabs and including over 150 receptors, enzymes, and ion channels, MK-7145 only exhibits three activities at <10 μM: acetyl cholinesterase, ACES, IC50=9.94 μM, somatostatin subtype 1, sst1 IC50=2.63 μM, and human serotonin transporter, SERT, IC50=0.12 μM. In a functional assay using HEK293 cells stably transfected with human SERT, uptake of 3H-serotonin is inhibited by MK-7145 with an IC50 value of 2.40±0.32 μM (n=5). The superior ROMK potency and in vivo efficacy of MK-7145, coupled with the fact that MK-7145 is a substrate of human Pgp (human Mdr1 BAAB ratio=12), should be able to impart a significant safety window with respect to the SERT off-target activity. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1435 mL | 10.7174 mL | 21.4348 mL | 42.8697 mL |
| 5mM | 0.4287 mL | 2.1435 mL | 4.2870 mL | 8.5739 mL |
| 10mM | 0.2143 mL | 1.0717 mL | 2.1435 mL | 4.2870 mL |
| 20mM | 0.1072 mL | 0.5359 mL | 1.0717 mL | 2.1435 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.