ML133 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $599 | Check With Us |
| 500mg | $999 | Check With Us |
| 1g | $1500 | Check With Us |
: Cat #: V0210 CAS #: 1222781-70-5 Purity ≥ 98%
Description: ML133 HCl, the hydrochloride salt of ML-133, is a novel, potent and selective inhibitor of the inward-rectifier potassium channel 2 (Kir2) identified from a high-throughput screening (HTS) of more than 300,000 small molecules.
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| Molecular Weight (MW) | 313.82 |
|---|---|
| Molecular Formula | C19H19NO.HCl |
| CAS No. | 1222781-70-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 63 mg/mL (200.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 6 mg/mL (19.1 mM) | |
| Synonyms | ML-133 HCl; ML133 HCl; ML 133 HCl; ML133 hydrochloride; ML 133 hydrochloride; ML-133 hydrochloride; 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride, CID 781301 hydrochloride, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride, SID 85281105 hydrochloride, VU0404943-1 hydrchloride |
| Protocol | In Vitro | ML133, which inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of Kir2.x family channels |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1865 mL | 15.9327 mL | 31.8654 mL | 63.7308 mL |
| 5mM | 0.6373 mL | 3.1865 mL | 6.3731 mL | 12.7462 mL |
| 10mM | 0.3187 mL | 1.5933 mL | 3.1865 mL | 6.3731 mL |
| 20mM | 0.1593 mL | 0.7966 mL | 1.5933 mL | 3.1865 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.