NS309
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $650 | Check With Us |
| 1g | $1100 | Check With Us |
| 5g | $2970 | Check With Us |
: Cat #: V26675 CAS #: 18711-16-5 Purity ≥ 99%
Description: NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).
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| Molecular Weight (MW) | 231.032 |
|---|---|
| Molecular Formula | C8H4Cl2N2O2 |
| CAS No. | 18711-16-5 |
| Synonyms | NS309; NS-309; NS 309. |
| Protocol | In Vitro | NS309 (40 nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3284 mL | 21.6420 mL | 43.2840 mL | 86.5681 mL |
| 5mM | 0.8657 mL | 4.3284 mL | 8.6568 mL | 17.3136 mL |
| 10mM | 0.4328 mL | 2.1642 mL | 4.3284 mL | 8.6568 mL |
| 20mM | 0.2164 mL | 1.0821 mL | 2.1642 mL | 4.3284 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.