Delcasertib (also known as KAI-9803 and BMS-875944) is a potent and selective δ-protein kinase C (δPKC) inhibitor that is composed of a peptide derived from the δV1-1 portion of δPKC (termed ‘cargo peptide’), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT₄₇₋₅₇; termed ‘carrier peptide’) via […]

Enzastaurin (formerly known as LY317615; DB-102; DB102 and LY-317615) is a novel, potent, and selective inhibitor of PKCβ (Protein kinase C) with potential antitumor activity.

Go 6983 (also known as GOE-6983; Go-6983; GOE6983; Go6983) is a novel and potent pan-PKC (protein kinase C) inhibitor with potential anticancer and cardioprotective activity.

Dequalinium Chloride (Dequavagyn; NSC-166454; NSC166454) is a potent PKC (protein kinase C) inhibitor with potential antitumor activity.

R59949 (R-59949) is a novel and potent Diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM.

Rottlerin (NSC-56346; NSC-94525), a naturally occuring compound isolated from Mallotus Philippinensis with the potential to be used as a chemotherapeutic agent for adrenocortical carcinoma, is a novel and specific protein kinase C (PKC) inhibitor with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM.

Oncrasin-1 is a novel and potent antitumor agent that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; it also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

Valrubicin is a semisynthetic analogue of the antineoplastic anthracycline antibiotic doxorubicin.

TAS-301 is a novel, potent and selective inhibitor of smooth muscle cell migration and proliferation and inhibits intimal thickening after balloon injury to rat carotid arteries.

Sotrastaurin (also known as AEB-071; AEB071; AEB 071) is an orally bioavailable, potent and selective pan-PKC inhibitor with potential antineoplastic activity.