Delcasertib | CAS 949100-39-4

Delcasertib

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50mg	$1850	Check With Us
100mg	$3250	Check With Us
200mg	$4875	Check With Us

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Cat #: V3529 CAS #: 949100-39-4 Purity ≥ 98%

Description: Delcasertib (also known as KAI-9803 and BMS-875944) is a potent and selective δ-protein kinase C (δPKC) inhibitor that is composed of a peptide derived from the δV1-1 portion of δPKC (termed 'cargo peptide'), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT₄₇₋₅₇; termed 'carrier peptide') via a disulfide bond.

References: Miyaji Y, et al. Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos. 2011 Oct;39(10):1946-53.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	2880.28
Molecular Formula	C120H199N45O34S2
CAS No.	949100-39-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vitro	Delcasertib (KAI-9803) is composed of a selective δ-protein kinase C (δPKC) inhibitor peptide derived from the δV1-1 portion of δPKC (termed “cargo peptide”), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT47–57; termed “carrier peptide”) via a disulfide bond
	In Vivo	Delcasertib (KAI-9803, a single intraperitoneal injection) in mice results in the selective inhibition of PKC translocation in the liver, kidney, lung, heart, and brain
	Animal model	Six-week-old male Crl:CD(SD) rats
	Dosages	1 mg/kg (Pharmacokinetic Analysis).
	Administration	Via the femoral vein.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.3472 mL	1.7359 mL	3.4719 mL	6.9438 mL
5mM	0.0694 mL	0.3472 mL	0.6944 mL	1.3888 mL
10mM	0.0347 mL	0.1736 mL	0.3472 mL	0.6944 mL
20mM	0.0174 mL	0.0868 mL	0.1736 mL	0.3472 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.