Midostaurin (formerly also known as PKC-412; CGP41251; PKC412; CGP 41251; PKC 412; PKC412A; trade name: Rydapt), a synthetic indolocarbazole compound, is a multi-targeted kinase inhibitor with potential with potential antiangiogenic and antineoplastic activities.

GF109203X (also known as GF109203-X; bisindolylmaleimide; GO-6850; GF-109203 X; BIMI; GF-109203X) is a novel, potent, highly selective, cell-permeable, and reversible PKC (protein kinase C) inhibitor with potential antitumor activity.

Ro 31-8220 is a novel and potent pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.