Midostaurin (PKC412)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1340	In Stock
500mg	$1950	In Stock
1g	$2925	In Stock

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Cat #: V1527 CAS #: 120685-11-2 Purity ≥ 98%

Description: Midostaurin (formerly also known as PKC-412; CGP41251; PKC412; CGP 41251; PKC 412; PKC412A; trade name: Rydapt), a synthetic indolocarbazole compound, is a multi-targeted kinase inhibitor with potential with potential antiangiogenic and antineoplastic activities.

References: Fabbro D, et al. PKC412--a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 2000 Feb;15(1):17-28.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	570.64
Molecular Formula	C35H30N4O4
CAS No.	120685-11-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >50 mg/mLr
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	trade name: Rydapt; PKC-412; CGP41251; PKC412; CGP 41251; PKC 412; PKC412A; PKC-412A; PKC 412A; CGP-41251;

Protocol	In Vitro	Midostaurin (PKC412) exhibits broad antiproliferative activity against a variety of tumors and normal cell lines in vitro and is capable of reversing PGP-mediated multidrug resistance in tumor cells in vitro. Cellular exposure to Midostaurin (PKC412) results in a dose-dependent increase in the G2/M phase of the cell cycle, along with increased polyploidy, apoptosis, and increased sensitivity to ionizing radiation
Protocol	In Vivo	Midostaurin (PKC412) strongly inhibits retinal neovascularization in mouse models as well as laser-induced choroidal neovascularization

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7524 mL	8.7621 mL	17.5242 mL	35.0484 mL
5mM	0.3505 mL	1.7524 mL	3.5048 mL	7.0097 mL
10mM	0.1752 mL	0.8762 mL	1.7524 mL	3.5048 mL
20mM	0.0876 mL	0.4381 mL	0.8762 mL	1.7524 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.