NSC5844 (also known as RE640), a 4-aminoquinoline derivative and a bisquinoline compound, is a novel and potent agonist of C-C chemokine receptor type 1 (CCR1).

Also known as 1,2,3,4,6-Pentagalloyl glucose (Penta-O-galloyl-β-D-glucose), DB03208 is a novel and potent inhibitor of receptor tyrosine kinase-like orphan receptor 1 (Ror1), isolated from various plants.

Bruceine A (NSC310616 and Dihydrobrusatol) is a naturally occuring quassinoid compound isolated from the dried fruits of Brucea javanica (L.); it has the potential for the treatment of canine babesiosis.

Eprinomectin (also known as MK-397) is an avermectin used as a veterinary topical endectocide with anthelmintic, insecticidal and miticidal activity.

PF-1022A (PF1022A) is a novel and potent N-methylated cyclooctadepsipeptides (CODPs) with excellent anthelmintic properties and acts as an ionophore.

Mefloquine HCl (Mefloquin) is a blood schizonticide which inhibits hemozoin formation, and is used as a phospholipid-interacting antimalarial drug. Mefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. Mefloquine can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS) may be used as a therapeutic modality to […]

Nitazoxanide (also known as NTZ; NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and a broad spectrum antiprotozoal agent with IC50 for canine influenza virus ranges from 0.17 to 0.21 μM. It was approved for treating human protozoan infections. Nitazoxanide reduces parasite growth in cell culture by more than 90% with little evidence of drug-associated cytotoxicity. […]

Fumagillin (formerly known as NSC9168) is a novel, potent, selective and irreversible/covalent inhibitor of Methionine aminopeptidase 2 (MetAP2), it is primarily used as an antibiotic / antimicrobial to treat microsporidiosis. Fumagillin is a complex natural product antibiotic isolated in 1949 from the microbial organism Aspergillus fumigatus. It covalently binds a key histidine residue of methionine […]

Nifurtimox (Bayer-2502; BAY 2502; trade name Lampit) is a 5-nitrofuran based antiprotozoal agent approved for use in the treatment of infections caused by trypanosomes such as Chagas disease and sleeping sickness.

Broxaldine is an antiprotozoal drug that can also be used in the treatment of leprosy. It was formerly given by mouth, with broxyquinoline, in the treatment of intestinal protozoal infections, including amoebiasis, but less toxic drugs are preferred. It has an InChI of 1S/C17H11Br2NO2/c1-10-7-8-12-13(18)9-14(19)16(15(12)20-10)22-17(21)11-5-3-2-4-6-11/h2-9H,1H3; and InChI KEY of IJTPLVAAROHGGB-UHFFFAOYSA-N; SMILES Code of CC1=NC2=C(C=C1)C(=CC(=C2OC(=O)C3=CC=CC=C3)Br)Br; Chemical/IUPAC name […]