Pamapimod (formerly known as R-1503; Ro-4402257) is a novel and selective inhibitor of p38 mitogen-activated protein kinase (MAPK) with immunomodulatory and anti-inflammatory effects.

PH-797804 (PH797804), a diarylpyridinone analog, is a novel, potent, selective and ATP-competitive inhibitor of p38 mitogen-activated protein (p38α) with potential anti-inflammatory and anticancer activity.

PD 169316 is a novel potent, cell-permeable and specific/selective inhibitor of p38 MAPK kinase with IC50 value of 89 nM.

AMG-548 dihydrochloride is a novel, orally bioactive, potent and selective inhibitor of p38α with Ki of 0.5 nM.

Skepinone-L (CBS-3830; CBS3830) is a novel, potent, selective and ATP-competitive inhibitor p38α-MAPK with potential anti-inflammatory activity.

AZD7624 is a novel, potent and selective inhaled p38 inhibitor with anti-inflammatory activity.

Acumapimod (also known as BCT197) is a potent and orally bioavailable small molecule inhibitor of the p38 MAP kinase (MAPK-mitogen-activated protein kinase) with an IC50 of less than 1 μM for p38α.

Cornuside is a novel and potent secoiridoid glucoside.

BMS-582949 (also known as PS540446) is a potent and highly selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM.

Adezmapimod (SB-203580; RWJ-64809; SB203580; RWJ 64809) is a novel and potent p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with the potential to treat Systemic lupus erythematosus (SLE).