Skepinone-L (CBS3830)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | Check With Us |
| 250mg | $2580 | Check With Us |
| 500mg | $3870 | Check With Us |
: Cat #: V0486 CAS #: 1221485-83-1 Purity ≥ 98%
Description: Skepinone-L (CBS-3830; CBS3830) is a novel, potent, selective and ATP-competitive inhibitor p38α-MAPK with potential anti-inflammatory activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 425.42 |
|---|---|
| Molecular Formula | C24H21F2NO4 |
| CAS No. | 1221485-83-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 85 mg/mL (199.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 85 mg/mL (199.8 mM) | |
| Solubility In Vivo | 0.5% methylcellulose: 30 mg/mL |
| SMILES Code | O=C1C2=CC=C(NC3=CC=C(F)C=C3F)C=C2CCC4=CC=C(OC[C@H](O)CO)C=C14 |
| Synonyms | Synonym: CBS3830; CBS-3830; CBS 3830; Skepinone-L |
| Protocol | In Vitro | Skepinone-L (CBS3830), the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3506 mL | 11.7531 mL | 23.5062 mL | 47.0124 mL |
| 5mM | 0.4701 mL | 2.3506 mL | 4.7012 mL | 9.4025 mL |
| 10mM | 0.2351 mL | 1.1753 mL | 2.3506 mL | 4.7012 mL |
| 20mM | 0.1175 mL | 0.5877 mL | 1.1753 mL | 2.3506 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.