A192 is a biochemical with the chemical name of N-(9H-fluoren-9-ylacetyl)-L-phenylalanine, also called (2S)-2-[[2-(9H-fluoren-9-yl)acetyl]amino]-3-phenylpropanoic acid.

A-176120 is a potent and selective inhibitor of the farnesyltransferase with IC50 of 1.2+/-0.3 nM. It is more selective over the closely related enzymes geranylgeranyltransferase I (GGTaseI) (IC(50) 423+/-1.8 nM), geranylgeranyltransferase II (GGTaseII) (IC(50) 3000 nM) and squalene synthase (SSase) (IC(50)>10000 nM). A-176120 inhibited ras processing in H-ras-transformed NIH3T3 cells and HCT116 K-ras-mutated cells (ED(50) […]

A 26771B is a sixteen-membered macrolide lactone antibiotic (Berkeleylactones) that was originally isolated from Penicillium turbatum. In recent years, promising synthetic derivatives of macrolactone natural product (-)-A26771B have been designed and synthesized both from semisynthesis and total synthesis. Further optimization led to the first synthesis of macrolactam analogs of (-)-A26771B with improved antibacterial activity and […]

A-317567 (A317567) is a novel non-amiloride inhibitor of the acid-sensing ion channel (ASIC) (IC50 = 1.025 μM) with antidepressant and antinociception effects. It acts on three distinct types of native ASIC currents evoked in acutely dissociated adult rat dorsal root ganglion (DRG) neurons. A-317567 produced concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an […]

A 10255 (also names as A10255, A-10255) is a macrolide type of complex and a thiopeptide antibiotics that is isolated from Streptomyces gardneri. The chemical name is (12Z,32Z,9Z)-9-ethylidene-6-(1-hydroxyethyl)-17-methyl-21,24-dimethylene-4,7,11,15,19,22-hexaoxo-5,8,12,16,20,23-hexaaza-1(4,2),10(2,5)-dioxazola-3(2,4),14,18(2,5)-trithiazola-2(2,3)-pyridinacyclotetracosaphane-26-carboxamide.

A1777 is a novel, potent and selective 5-lipoxygenase inhibitor that can reduce proliferation of leukocytes without affecting the eosinophils of mast cells. 5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a […]

A30641 is a new antibiotic with high in vitro activity against Gram-positive bacteria and fungi. It was originally isolated from a strain of Aspergillus tamarii. Chemical and physical characterization indicate that it is a member of the class of antibiotics containing the epidithiodiketopiperazine moiety.

A2315A is a new antibiotics produced by Actinoplanes philippinensis. Antibiotic A2315A is a new member of the virginiamycin family of antibiotics. Physical and chemical data indicate that it is related to ostreogrycin A.

LLY-284 (LLY284) is a negative control and tool compound for LLY-283. It is a diastereomer of LLY-283 but was much less active. LLY-283 (LLY283) is the first-in-class and selective SAM-competitive inhibitor of PRMT5 (protein arginine methyltransferase 5) with antitumor activity. LLY-283 inhibited PRMT5 enzymatic activity in vitro and in cells with IC50 values of 22 […]

A-130C is a novel and potent polyether antibiotic originally isolated from the metabolites of strepto,yces hygroscopicus by a Japanese research group in 1980.